1. Boekema P.J. et al. (2001) Functional bowel symptoms in a general Dutch population and associations with common stimulants. Neth J Med, 59(1):23-30.
  2. Boekema P.J. et al. (1999a) Chapter 4: Prevalence of functional bowel symptoms in a general Dutch population and associations with use of alcohol, coffee and smoking. Coffee and upper gastrointestinal motor and sensory functions, Zeist (the Netherlands).
  3. Boekema P.J. et al. (1999b) Effect of coffee on gastroesophageal reflux in patients with reflux disease and healthy controls. Eur J Gastroenterol Hepatol, 11:1271-1276.
  4. Haug T.T. et al. (1995) What Are the Real Problems for Patients with Functional Dyspepsia? Scan J Gastroenterol, 30(2):97-100.
  5. Nandurkar S. et al. (1998) Dyspepsia in the community is linked to smoking and aspirin use but not to Helicobacter pylori infection. Arch Intern Med, 158(13):1427-1433.
  6. Moayyedi P. et al. (2000) The Proportion of Upper Gastrointestinal Symptoms in the community Associated With Helicobacter pylori, Lifestyle Factors, and Nonsteroidal Anti-inflammatory Drugs. Am J Gastroenterol, 95(6):1448-1455.
  7. Bolin T.D. et al. (2000) Esophagogastroduodenal Diseases and Pathophysiology, Heartburn: Community perceptions. J Gastroenterol Hepatol, 15:35-39.
  8. Nilsson M. et al. (2004) Lifestyle related risk factors in the aetiology of gastroesophageal reflux. Gut, 53:1730-1735.
  9. Zheng Z. et al. (2007) Lifestyle factors and Risks for Symptomatic Gastroeosophageal Reflux in Monozy- gotic Twins. Gastroenterology, 132:87-95.
  10. Kaltenbach T. et al. (2006) Review: sparse evidence supports lifestyle modifications for reducing symptoms of gastroesophageal reflux disease. Arch Intern Med, 166:965-971.
  11. Kim J. et al. (2013) Association between coffee intake and gastroesophageal reflux disease: a meta-analysis, Diseases of the Esophagus, 27(4):311-317.
  12. Dore M.P. et al. (2007) Diet, Lifestyle and Gender in Gastro-Esophageal Reflux Disease. Dig Dis Sci, 53(8):2027-2032.
  13. Pandeya N. et al. (2011) Prevalence and determinants of frequent gastroesophageal reflux symptoms in the Australian community. Diseases of the Esophagus, 25(7):573-83.
  14. Pehl C. et al. (1997) The effect of decaffeination of coffee on gastroesophageal reflux in patients with reflux disease. Alim Pharm Ther, 11:483-486.
  15. Rosenstock S. et al. (2003) Risk factors for peptic ulcer disease: a population based prospective cohort study comprising 2,416 Danish adults. Gut, 52:186-193.
  16. Shimamoto T. et al. (2013) No association of coffee consumption with gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive reflux disease: a cross-sectional study of 8,013 healthy subjects in Japan, PLoS One, 8(6):e65996.
  17. Aldoori W.H. et al. (1997) A Prospective Study of Alcohol, Smoking, Caffeine, and the Risk of Duodenal Ulcer in Men. Epidemiology, 4(8):420-424.
  18. Loomis D. et al. (2016) Carcinogenicity of drinking coffee, mate, and very hot beverages. The Lancet Oncology, 17(7):877-878.
  19. Botelho F. et al. (2006) Coffee and gastric cancer: systematic review and meta-analysis. Cad Saude Publica, 22:889–900.
  20. Elta G.H. et al. (1990) Comparison of coffee intake and coffee-induced symptoms in patients with duodenal ulcer, nonulcer dyspepsia, and normal controls. Am J Gastroenterol, 85:1339-1342.
  21. Brown S.R. et al. (1990) Effect of coffee on distal colon function. Gut, 31:450-453.
  22. Rao S.S.C. et al. (1998) Is coffee a colonic stimulant. Eur J Gastroenterol Hepatol, 10:113-118.
  23. Sloots C.E.J. et al. (2005) Stimulation of defecation: Effects of coffee use and nicotine on rectal tone and visceral sensitivity. Scan J Gastroenterol, 40:808-813.
  24. Simren M. et al. (2001) Food-Related Gastrointestinal Symptoms in the Irritable Bowel Syndrome. Digestion, 63:108-115.
  25. Yu X. et al. (2011) Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer, 15:11-96.
  26. Tavani A. et al. (2004) Coffee, decaffeinated coffee, tea and cancer of the colon and rectum: a review of epidemiological studies 1990-2003. Cancer Causes Control, 15:743-57.
  27. Giovannucci E. (1998) Meta-analysis of coffee consumption and risk of colorectal cancer. Am J Epidemiol, 147:1043–52.
  28. Galeone C. et al. (2010) Coffee consumption and risk of colorectal cancer: a meta-analysis of case–control studies. Cancer Causes Control, 21:1949-59.
  29. Leitzmann M.F. et al. (1999) A prospective study of coffee consumption and risk of symptomatic gallstone disease in men. JAMA, 281:2106-2112.
  30. Leitzmann M.F. et al. (2002) Coffee intake is associated with lower risk of symptomatic gallstone disease in women. Gastroenterol, 123:1823-1830.
  31. Larsson S.C. et al. (2007) Coffee consumption and liver cancer: a meta-analysis. Gastroenterology, 132:1740-1745.
  32. Bravi F. et al. (2007) Coffee drinking and hepatocellular carcinoma risk: a meta-analysis. Hepatology, 46:430-435.
  33. WCRF: Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective. (2007) Available from:
  34. Luo J. et al. (2007) Green tea and coffee intake and risk of pancreatic cancer in a large-scale, population-based cohort study in Japan (JPHC study). Eur J Cancer Prev, 16:542-8.
  35. Dong J. et al. (2011) Coffee drinking and pancreatic cancer risk: a meta-analysis, World Journal of Gastroenterology, 17(9):1204-10.
  36. Turati F. et al. (2011) A meta-analysis of coffee consumption and pancreatic cancer, Annals of Oncology, 23(2):311-8.
  37. Turati F. et al. (2011) Coffee, decaffeinated coffee, tea, and pancreatic cancer risk: a pooled-analysis of two Italian case-control studies. Eur J Cancer Prevention, 20(4):287–292.
  38. US National Library of Medicine, ‘Gastro Intestinal Tract (GI Tract). Available at:
  39. Boekema P.J. (1999) Coffee and gastrointestinal function: facts and fiction. A review. Scand J Gastroenterol, 230:35-9.
  40. Saab S. et al. (2014) Impact of coffee on liver disease a systematic review. LiverInt, 34(4):495-504.